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A stability-indicating LC assay method was developed and validated for the quantitative determination of doripenem and biapenem in pharmaceutical dosage forms in the presence of degradation products formed during forced degradation studies. An isocratic RP-HPLC method was developed with a C-18 (250 mm × 4.6 mm, 5 μm) column and 12 mM ammonium acetate-acetonitrile (96:4 υ/υ) as mobile phase. The flow...
The ACGT Oncosimulator is an integrated Grid-based system, under development within a 25-partner European-Japanese project, for patient-specific simulation of the response of a tumour and surrounding tissue to various forms of therapy. The validation of the simulation code is an activity requiring extensive human-driven visual investigation of the influence of each of the dozens of parameters to the...
The RecipeSheet is a spreadsheet-inspired environment for building applications that support the parallel, side-by-side exploration of alternative processing results. Our early investigations suggest that such an environment can be valuable for educational activities in which a student's understanding of some topic would be improved by being able to explore and compare many alternative cases. In this...
The Bead visualization system employs a fast algorithm for laying out high-dimensional data in a low-dimensional space, and a number of features added to 3D visualizations to improve imageability. We describe recent work on both aspects of the system, in particular a generalization of the data types laid out and the implementation of imageability features in a 2D visualization tool. The variety of...
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