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Allosteric modulators bind sites distinct from orthosteric ligands, allowing for improved spatiotemporal control of receptors and greater subtype selectivity. However, we recently showed that allosteric ligands previously classified as selective for select Class C G protein‐coupled receptors (GPCRs) had unappreciated activity at other off‐target receptors, in some cases higher affinity, within the...
We describe a method to compute the prototypical shapes for object categories using the shock graph representation. Given a set of category exemplars, we determine a prototypical shape for this category by estimating the Karcher mean of the shock graphs of the exemplar shapes. The method is described in three steps. First, we derive an iterative method to average N points in an abstract continuous...
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