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Rodent models are frequently used in aging research to investigate biochemical age effects and aid in the development of therapies for pathological and non-pathological age-related degenerative processes. In order to validate the use of animal models in aging research and pave the way for longitudinal intervention-based animal studies, the consistency of cerebral aging processes across species needs...
Simultaneous dual-tracer technique (SDTT) was proposed 30 years ago to discriminate between two PET radiotracer concentrations based on their different radioactive decay rates. This study evaluates the performance of SDTT in static studies using 2-deoxy-2-18F-fluoro-D-glucose (18F-FDG) and 13N-ammonium (13N-NH4+) as radiotracers. SDTT was applied to a phantom. The influence of applying SDTT on either...
Position Emission Tomography (PET) allows the in-vivo monitoring of functional processes in the body. However its limited spatial resolution induces Partial Volume Effect (PVE), which leads to a loss of signal in tissues of size similar to the Point Spread Function (PSF) of the imaging device and induces activity spillover between adjacent structures with different amounts of activity. The aim of...
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