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We developed a new comprehensive cardiopulmonary model that takes into account the mutual interactions between the cardiovascular and the respiratory systems along with their short-term regulatory mechanisms. The model includes the heart, systemic and pulmonary circulations, lung mechanics, gas exchange and transport equations, and cardio-ventilatory control. Results show good agreement with published...
Conditions characterized by a fall in cardiac output are associated with alterations in cardiopulmonary variables and activation of cardiovascular and respiratory control mechanisms. In order to study these complex relationships, we developed a comprehensive cardiopulmonary model consisting of a circulation, a respiration and a metabolism block. In this work, the model is used to simulate cardiovascular...
Capnography, the monitoring of expired carbon dioxide (CO2 ) has been employed clinically as a non-invasive measure for the adequacy of ventilation of the alveoli of the lung. In combination with air flow measurements, the capnogram can be used to estimate the partial pressure of CO2 in the alveolar sacs. In addition, physiologically relevant parameters, such as the extent of CO2 rebreathing, the...
Several recent studies have established a correlation between tight glucose control and decreased perioperative morbidity and mortality in surgical and critically ill patients. We hypothesize that a progressive increase in delay in implementing insulin infusion rate changes would result in a progressively longer time to target glucose level and a progressive decrease in the percentage of time spent...
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