Search results for: R. Hegde

Items from 1 to 20 out of 117 results

article

Early and consistent pattern of proximal weakness in GNE myopathy

Satish V. Khadilkar, Amit D. Chaudhari, Madhu B. Singla, Rashna S. Dastur, more

Background GNE myopathy is widely regarded as a distal myopathy. Involvement of proximal musculature in this condition has not been systematically studied. Methods The phenotype of genetically confirmed patients with GNE myopathy was analyzed. Fourteen groups of muscles were evaluated with Medical Research Council (MRC) grading and the average muscle scores (AMS:1–10) were calculated. Results...

article

Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome

John‐Paul Berauer, Anya I. Mezina, David T. Okou, Aniko Sabo, more

Hepatology > 70 > 3 > 899 - 910

Biliary atresia (BA) is the most common cause of end‐stage liver disease in children and the primary indication for pediatric liver transplantation, yet underlying etiologies remain unknown. Approximately 10% of infants affected by BA exhibit various laterality defects (heterotaxy) including splenic abnormalities and complex cardiac malformations—a distinctive subgroup commonly referred to as the...

article

Isolation and evolutionary analysis of Australasian topotype of bluetongue virus serotype 4 from India

Y. V. Reddy, B. Susmitha, S. Patil, Y. Krishnajyothi, more

Transboundary and Emerging Diseases > 65 > 2 > 547 - 556

Bluetongue (BT) is a Culicoides‐borne disease caused by several serotypes of bluetongue virus (BTV). Similar to other insect‐borne viral diseases, distribution of BT is limited to distribution of Culicoides species competent to transmit BTV. In the tropics, vector activity is almost year long, and hence, the disease is endemic, with the circulation of several serotypes of BTV, whereas in temperate...

article

Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations

Haritima Joshi, Aswathi R. Hegde, Pallavi K. Shetty, Hemanth Gollavilli, more

Photodermatology, Photoimmunology & Photomedicine > 34 > 1 > 69 - 81

Background The aim of this study was to develop sunscreen creams containing polymeric nanoparticles (NPs) of naringenin for photoprotective and antioxidant effects. Methods Polymeric NPs of naringenin were prepared and optimized. The NPs were incorporated into sunscreen creams and evaluated for in vitro and in vivo skin retention. Results The optimized naringenin NPs showed a size of 131.2 nm,...

article

Clinical implications and considerations for evaluation of in silico algorithms for use with ACMG/AMP clinical variant interpretation guidelines

Lora J. H. Bean, Madhuri R. Hegde

Genome Medicine > 2017 > 9 > 1 > 1-3

Clinical genetics laboratories have recently adopted guidelines for the interpretation of sequence variants set by the American College of Medical Genetics (ACMG) and Association for Molecular Pathology (AMP). The use of in silico algorithms to predict whether amino acid substitutions result in human disease is inconsistent across clinical laboratories. The clinical genetics community must carefully...

article

Dual Infection with Bluetongue Virus Serotypes and First‐Time Isolation of Serotype 5 in India

D. Hemadri, S. Maan, M. M. Chanda, P. P. Rao, more

Transboundary and Emerging Diseases > 64 > 6 > 1912 - 1917

Bluetongue is endemic in India and has been reported from most Indian states. Of late, the clinical disease is most frequently seen in the states of Andhra Pradesh, Telangana (erstwhile Andhra Pradesh state), Tamil Nadu and Karnataka. Our analysis of diagnostic samples from bluetongue outbreaks during 2010–2011 from the state of Karnataka identified bluetongue virus (BTV) serotype 5 (BTV‐5) for the...

article

Indian propolis ameliorates the mitomycin C-induced testicular toxicity by reducing DNA damage and elevating the antioxidant activity

Sandhya Kumari, Guruprasad Nayak, Sonu T. Lukose, Sneha Guruprasad Kalthur, more

Biomedicine & Pharmacotherapy > 2017 > 95 > C > 252-263

Development of excellent curative therapy for most of the malignancies has resulted in a growing population of cancer survivors who are at increased risk for a variety of health problems including infertility. Therefore, fertility preservation has become an important issue during cancer treatment in recent years. Combination therapy with natural agents such as vitamins, antioxidants, dietary supplements,...

article

The use of BirA-BAP system to study the effect of US2 and US11 on MHC class I heavy chain in cells

S. Gauthami, Deepak Kumar, K.S.R. SivaSai, Nagendra R. Hegde

Immunology Letters > 2017 > 190 > C > 233-239

Biotinylation has been extensively used for antibody tagging, affinity-based purification, and in protein/DNA-protein interaction studies. Here we describe the use of biotinylation to study the turn-over of proteins in cells. We use the prokaryotic biotin ligase (BirA) to biotinylate the human leukocyte antigen (HLA)-A2 (A2) heavy chain (HC), which was engineered to contain a biotin acceptor peptide...

article

Biophysical and socio‐economic causes for increasing fallow land in Tamil Nadu

S. Dharumarajan, M. Lalitha, A. Natarajan, L. G. K. Naidu, more

Soil Use and Management > 33 > 3 > 487 - 498

The question of increasing fallow land assumes significance at national and international levels due to the decline in net cultivated area and increasing population. Biophysical characteristics of farmland and socio‐economic conditions of farmers are responsible for the increasing fallow. This study was carried out to assess the extent of permanent fallow and identify causes for its increase. High‐resolution...

article

First-in-Human Closed-Chest Transcatheter Superior Cavopulmonary Anastomosis

Kanishka Ratnayaka, John W. Moore, Rodrigo Rios, Robert J. Lederman, more

Journal of the American College of Cardiology > 2017 > 70 > 6 > 745-752

In the care of patients with congenital heart disease, percutaneous interventional treatments have supplanted many surgical approaches for simple lesions, such as atrial septal defect. By contrast, complex congenital heart defects continue to require open-heart surgery. In single-ventricle patients, a staged approach is employed, which requires multiple open-heart surgeries and significant attendant...

article

Peptide dendrimer-conjugates of ketoprofen: Synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery

Aswathi R Hegde, Prarthana V Rewatkar, Jyothsna Manikkath, Karnaker Tupally, more

European Journal of Pharmaceutical Sciences > 2017 > 102 > C > 237-249

The aim of this study was to evaluate skin delivery of ketoprofen when covalently tethered to mildly cationic (2⁺ or 4⁺) peptide dendrimers prepared wholly by solid phase peptide synthesis. The amino acids glycine, arginine and lysine formed the dendrimer with ketoprofen tethered either to the lysine side-arm (N_ε) or periphery of dendrimeric branches. Passive diffusion, sonophoresis- and iontophoresis-assisted...

article

Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen

Jyothsna Manikkath, Aswathi R. Hegde, Guruprasad Kalthur, Harendra S. Parekh, more

International Journal of Pharmaceutics > 2017 > 521 > 1-2 > 110-119

The aim of this study was to determine the individual and combined effects of peptide dendrimers and low frequency ultrasound on the transdermal permeation of ketoprofen. Arginine terminated peptide dendrimers of varying charges (4⁺, 8⁺ and 16⁺, named as A4. A8 and A16 respectively) were synthesized and characterized. Ketoprofen was subjected to passive, peptide dendrimer-assisted and sonophoretic...

article

Skin Delivery of EGCG and Silibinin: Potential of Peptide Dendrimers for Enhanced Skin Permeation and Deposition

Pallavi Krishna Shetty, Jyothsna Manikkath, Karnaker Tupally, Ganesh Kokil, more

AAPS PharmSciTech > 2017 > 18 > 6 > 2346-2357

The aim of the present study was to evaluate the ability of the peptide dendrimers to facilitate transdermal delivery of antioxidants, silibinin, and epigallocatechin-3-gallate (EGCG). Drug–peptide dendrimer complexes were prepared and evaluated for their ability to permeate across the skin. The data revealed the ready formation of complexes between drug and peptide dendrimer in a molar ratio of 1:1...

article

Gene Variant Databases and Sharing: Creating a Global Genomic Variant Database for Personalized Medicine

Lora J.H. Bean, Madhuri R. Hegde

Human Mutation > 38 > 1 > 122 - 122

article

Evaluation of wound healing property of Caesalpinia mimosoides Lam.

Pradeep Bhaskar Bhat, Shruti Hegde, Vinayak Upadhya, Ganesh R. Hegde, more

Journal of Ethnopharmacology > 2016 > 193 > C > 712-724

Caesalpinia mimosoides Lam. is one of the important traditional folk medicinal plants in the treatment of skin diseases and wounds used by healers of Uttara Kannada district of Karnataka state (India). However scientific validation of documented traditional knowledge related to medicinal plants is an important path in current scenario to fulfill the increasing demand of herbal medicine.The study was...

article

Multidrug resistant pathogenic bacterial biofilm inhibition by Lactobacillus plantarum exopolysaccharide

Pradeepa, Akshay D. Shetty, Koshi Matthews, Aswathi R. Hegde, more

Bioactive Carbohydrates and Dietary Fibre > 2016 > 8 > 1 > 7-14

The purpose of the present study was to evaluate the antibiofilm activity of the exopolysaccharide (EPS) isolated from fish derived Lactobacillus plantarum. The polysaccharide was purified by column chromatography and characterized by using Fourier transform infrared spectroscopy (FTIR), ¹H NMR, HPLC, scanning electron microscope (SEM) and zeta potential (ζ). The EPS consist of three major sugars...

article

Isolation of Bluetongue Virus 24 from India – An Exotic Serotype to Australasia

Y. Krishnajyothi, S. Maan, K. Kandimalla, N. S. Maan, more

Transboundary and Emerging Diseases > 63 > 4 > 360 - 364

Bluetongue (BT) is a viral disease of ruminants and is caused by different serotypes of bluetongue virus (BTV), which is transmitted by several species of Culicoides midges. The disease is endemic in tropical areas, and incursions have been observed in some of the temperate areas. Twenty‐seven recognized serotypes of BTV have been reported so far. Some serotype viruses have been shown to circulate...

article

Su1322 The Role of KRAS on Management of Indeterminate Pancreatic Cysts: A Retrospective Study

Nikola S. Natov, Laura C. Horton, Sanjay R. Hegde

Gastrointestinal Endoscopy > 2016 > 83 > 5(S) > AB351-AB352

article

Genomic Sequencing Procedure Microcosting Analysis and Health Economic Cost-Impact Analysis

Linda M. Sabatini, Charles Mathews, Devon Ptak, Shivang Doshi, more

The Journal of Molecular Diagnostics > 2016 > 18 > 3 > 319-328

The increasing use of advanced nucleic acid sequencing technologies for clinical diagnostics and therapeutics has made vital understanding the costs of performing these procedures and their value to patients, providers, and payers. The Association for Molecular Pathology invested in a cost and value analysis of specific genomic sequencing procedures (GSPs) newly coded by the American Medical Association...

article

Gene Variant Databases and Sharing: Creating a Global Genomic Variant Database for Personalized Medicine

Lora J.H. Bean, Madhuri R. Hegde

Human Mutation > 37 > 6 > 559 - 563

Revolutionary changes in sequencing technology and the desire to develop therapeutics for rare diseases have led to the generation of an enormous amount of genomic data in the last 5 years. Large‐scale sequencing done in both research and diagnostic laboratories has linked many new genes to rare diseases, but has also generated a number of variants that we cannot interpret today. It is clear that...

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BLUETONGUE VIRUS (9)
INDIA (6)
VEHICLES (6)
BLUETONGUE (5)
ANTIOXIDANT (4)
AUTOMOTIVE ELECTRONICS (4)
ECU (4)
LOAD BALANCING (4)
LOAD MANAGEMENT (4)
RESOURCE ALLOCATION (4)
SOFTWARE (4)
VACCINE (4)
CAN (3)
CLINICAL GENETICS (3)
COMMUNICATION INFRASTRUCTURE (3)
ELECTRONIC CONTROL UNITS (3)
NANOCOMPOSITES (3)
POLYPROPYLENE (3)
PYRUVATE (3)
SEQUENCING (3)
SEROTYPE (3)
SKIN PERMEATION (3)
TOPOTYPE (3)
UTTARA KANNADA (3)
VEHICLE DYNAMICS (3)
ADDITIVES (2)
AUSTRALASIA (2)
AUTOMOTIVE ENGINEERING (2)
AUTOMOTIVE SUBSYSTEM (2)
AUTOSAR (2)
CELL CULTURE (2)
CLIMATE (2)
COLLABORATION (2)
COMPUTER ARCHITECTURE (2)
COMPUTERS (2)
CONSUMER ELECTRONICS (2)
CONTROLLER AREA NETWORKS (2)
COUPLINGS (2)
CPU (2)
DEEP SUBMICRON NOISE (2)
DELAY (2)
DELAYS (2)
DIAGNOSTICS (2)
ENERGY DISSIPATION (2)
ETHNOMEDICINE (2)
GENOME SEQUENCE (2)
H1N1 (2)
HEURISTIC ALGORITHMS (2)
INFLUENZA (2)
INTEGRATED CIRCUIT NOISE (2)
ISOLATION (2)
KARNATAKA (2)
KETOPROFEN (2)
LOGIC GATES (2)
MORPHOLOGY (2)
MUTATION (2)
NEXT GENERATION SEQUENCING (2)
OEM (2)
OXIDATIVE STRESS (2)
PAIR PROGRAMMING (2)
PANDEMIC (2)
PHYLOGENETIC ANALYSIS (2)
PROGRAM PROCESSORS (2)
PROGRAMMING (2)
SAFETY (2)
SENSORS (2)
SONOPHORESIS (2)
SUPPLY VOLTAGE (2)
TRANSDERMAL (2)
TYPING (2)
VEHICLE COMFORT (2)
VEHICLE NETWORK (2)
VEHICLE RELIABILITY (2)
VIRUS MOVEMENT (2)
VLSI (2)
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WESTERN GHATS (2)
1H AND 1 3 C NMR SPECTRA (1)
AL 2 O 3 (1)
HFO 2 (1)
0.5 DB (1)
0.5 DB DEGRADATION (1)
4G MOBILE COMMUMICATION (1)
4G MOBILE COMMUNICATION (1)
ABSENT PECTORAL MUSCLES (1)
ACANTHACEAE (1)
ADAPTIVE CONTROL (1)
ADCS (1)
ADDITIVE (1)
ADULT CONGENITAL HEART DISEASE (1)
ADVENTITIOUS AGENTS (1)
ALGORITHM (1)
ALGORITHMIC NOISE-TOLERANCE (1)
ALLELE-SPECIFIC PEPTIDE MOTIFS (1)
AMERICAN COLLEGE OF MEDICAL GENETICS (ACMG) (1)
ANDROGRAPHIS WIGHTIANA (1)
ANTIBIOFILM ACTIVITY (1)
ANTIBIOTIC SUSCEPTIBILITY (1)
ANTIGEN (1)
ANTIGEN PROCESSING AND PRESENTATION (1)
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Gastrointestinal Endoscopy (5)
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Tetrahedron Letters (4)
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Muscle & Nerve (3)
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Immunology Letters (1)
Indian Journal of Microbiology (1)
Indian Journal of Thoracic and Cardiovascular Surgery (1)
International Journal for Parasitology (1)
International Journal of Pharmaceutics (1)
Journal of Pierre Fauchard Academy (India Section) (1)
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Journal of the American College of Cardiology (1)
Journal of the Geological Society of India (1)
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Medical Hypotheses (1)
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Photodermatology, Photoimmunology & Photomedicine (1)
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Polymer International (1)
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Trends in Immunology (1)
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INFONA - science communication portal

Search results for: R. Hegde

Early and consistent pattern of proximal weakness in GNE myopathy

Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome

Isolation and evolutionary analysis of Australasian topotype of bluetongue virus serotype 4 from India

Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations

Clinical implications and considerations for evaluation of in silico algorithms for use with ACMG/AMP clinical variant interpretation guidelines

Dual Infection with Bluetongue Virus Serotypes and First‐Time Isolation of Serotype 5 in India

Indian propolis ameliorates the mitomycin C-induced testicular toxicity by reducing DNA damage and elevating the antioxidant activity

The use of BirA-BAP system to study the effect of US2 and US11 on MHC class I heavy chain in cells

Biophysical and socio‐economic causes for increasing fallow land in Tamil Nadu

First-in-Human Closed-Chest Transcatheter Superior Cavopulmonary Anastomosis

Peptide dendrimer-conjugates of ketoprofen: Synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery

Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen

Skin Delivery of EGCG and Silibinin: Potential of Peptide Dendrimers for Enhanced Skin Permeation and Deposition

Gene Variant Databases and Sharing: Creating a Global Genomic Variant Database for Personalized Medicine

Evaluation of wound healing property of Caesalpinia mimosoides Lam.

Multidrug resistant pathogenic bacterial biofilm inhibition by Lactobacillus plantarum exopolysaccharide

Isolation of Bluetongue Virus 24 from India – An Exotic Serotype to Australasia

Su1322 The Role of KRAS on Management of Indeterminate Pancreatic Cysts: A Retrospective Study

Genomic Sequencing Procedure Microcosting Analysis and Health Economic Cost-Impact Analysis

Gene Variant Databases and Sharing: Creating a Global Genomic Variant Database for Personalized Medicine

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