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Rupture of abdominal aortic aneurysm (AAA), having a mortality rate of 50-75%, ranks as the 13th leading cause of death in the US. The ability to reliably predict the risk of rupture of AAA on a patient-specific basis could vastly improve the clinical management of these patients. Computed tomography scans of patients that arrived at Stony Brook University Hospital emergency room, with contained ruptures...
Human blood platelets function in wound healing, inflammation, and clot formation. Despite significant progress molecular mechanisms of megakaryocyte maturation remain poorly characterized. We have applied a customized, platelet-specific oligonucleotide gene chip to dissect the molecular events of megakaryopoiesis. CD34 hematopoietic stem cells obtained from 2 distinct adult human donors were differentiated...
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