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A 0.13-micron CMOS fully integrated 48-channel UWB label-free DNA analysis SoC is demonstrated in prostate cancer screening. The 3mm×3mm die includes 578 nanostructured DNA sensors, 48 pH sensors, and 48 temperature sensors and reuses key circuits for cyclic voltammetry, amperometry and temperature regulation.
In this paper, a new concept to achieve improved probe–target recognition has been devised by introducing a novel class of DNA-functionalized three-dimensional (3D), stand-free, and nanostructured electrodes. The gold nanofibrous electrodes were created using MHZ ultrafast laser material processing in air at ambient conditions. The developed nanofibrous DNA biosensor was characterized by cyclic voltammetry...
Prostate cancer is the most commonly diagnosed cancer among North American men. The recent discovery of altered genes that play an underlying role in prostate cancer development has made the sequence-specific detection of nucleic acids especially important. Multiplexed detection using electronic readout would permit sensitive, reliable, fast and inexpensive identification of molecular biomarkers in...
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