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This study investigated whether treatment with IFN-α and ribavirin (RBV) reduces 2LTR circular HIV DNA in addition to the total and integrated HIV DNA. Two groups of patients were enrolled. Group 1 comprised HIV/HCV co-infected patients who were treated with highly active antiretroviral therapy (HAART), IFN-α and RBV for 48weeks. After the 48weeks of treatment, IFN-α and RBV treatment was discontinued...
The optimal parameters of candidate measures established by importance sampling are usually obtained by minimizing the quadratic criterion. To begin with, in this paper a scheme is developed for finding the alternative measure that is optimal in the sense that the p-order relative moment is minimized. Secondly, a necessary and sufficient condition for asymptotic efficiency of the optimal change of...
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