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The way cells are organized within a tissue dictates how they sense and respond to extracellular signals, as cues are received and interpreted based on expression and organization of receptors, downstream signaling proteins, and transcription factors. Part of this microenvironmental context is the result of forces acting on the cell, including forces from other cells or from the cellular substrate...
Reducing a program's instruction count can improve cache behavior and bandwidth utilization, lower power consumption, and increase overall performance. Nonetheless, code density is an often overlooked feature in studying processor architectures. We hand-optimize an assembly language embedded benchmark for size on 21 different instruction set architectures, finding up to a factor of three difference...
PARSEC is a reference application suite used in industry and academia to assess new chip multiprocessor (CMP) designs. No investigation to date has profiled PARSEC on real hardware to better understand scaling properties and bottlenecks. This understanding is crucial in guiding future CMP designs for these kinds of emerging workloads. We use hardware performance counters, taking a systems-level approach...
When creating architectural tools, it is essential to know whether the generated results make sense. Comparing a toolpsilas outputs against hardware performance counters on an actual machine is a common means of executing a quick sanity check. If the results do not match, this can indicate problems with the tool, unknown interactions with the benchmarks being investigated, or even unexpected behavior...
The mitogen activated protein (MAP) kinase cascade, leading to extracellular-regulated kinase (ERK) activation, is a key regulator of cell growth and proliferation. The effects of ERK are mediated by differences in ERK signalling dynamics, including magnitude and duration. In vivo, ERK signalling is stimulated by both growth factors and adhesion signals. A model for adhesion-mediated ERK activation...
Le cancer du sein, de part son incidence croissante et les frequentes resistances a la chimiotherapie rencontrees, constitue un veritable probleme de societe. La lutte efficace contre cette maladie effrayante necessite une meilleure connaissance des mecanismes de la cancerogenese mammaire. Notre but est d'etablir l'importance du role de la matrice nucleaire (MN) dans la perturbation du systeme regulateur...
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