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Drug disposition after topical application to the skin has not been fully elucidated, especially after repeated application. We conducted a clinical trial to evaluate the pharmacokinetics in the stratum corneum of healthy adults after repeated application of lanoconazole cream as a model drug. We applied 25 mg of 1% lanoconazole cream onto the pre‐specified areas on the participants' back once daily...
A two-wheeled vehicle is a MIMO (multiple-input multiple-output) object. While it is difficult for a beginner rider to operate a two-wheeled vehicle, a skilled rider is able to operate the vehicle cleverly using human MIMO knowledge. In this paper, an intelligent 2-wheeled vehicle driving support (i2DS) system, which applies the intelligent MIMO control (iMIMOc) method that can be built using human...
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