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This paper deals with the performance of some numerical integration methods for Ordinary Differential Equations in real time applications involving stiffness. After summarising the main results about accuracy and stability of some well known schemes, the point of view of the control is emphasized, by showing the impact of the numerical integration on the dynamics of the discretized model. Moreover...
Target Controlled Infusion (TCI) systems are based in drug pharmacokinetic and pharmacodynamic models implemented in an algorithm to drive an infusion pump. Infusion control algorithms have been designed, implemented and validated for several anesthetic drugs, devices and controllers. The maintenance phase in these algorithms is represented by an equation that compensates the loss of drug from the...
The aim of this study was to evaluate the prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) among pigs and estimate the impact of this animal reservoir on human healthcare. Nasal swabs were derived from 1,600 pigs at 40 German farms. The MRSA were characterized using S. aureus protein A (spa) typing, multilocus sequence typing (MLST) and detection of toxin...
The Cerebral State Index (CSI) is an electroencephalogram derived signal representing the depression of central nervous activity produced by anesthetic drugs. In this study, a nonlinear model was developed to describe the CSI tendency during general anesthesia in dogs, by evaluating the effect of the anesthetic drug propofol. The model was based on a compartmental and Hill Equation structure with...
This work presents the development of a software for data acquisition and control (ASYS) on a clinical setup. Similar to the industrial Supervisory Control And Data Acquisition (SCADA) the software assembles a target controlled infusion (TCI) monitoring and supervisory control data in real time from devices in a surgical room. The software is not a full controller since the TCI systems comprehend...
The goal of this study was to obtain models that described the relation between the anaesthetic drug infusions (propofol) and an electroencephalogram (EEG) derived index (Cerebral State Index - CSI) during general anaesthesia in dogs. The first phase integrated the adaptation of hardware for EEG acquisition and exploration for the best electrodes position in dogs skull. The clinical protocol implementation...
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