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Preliminary experiments showed that MC-1 magnetotactic bacteria (MTB) could be used for the delivery of therapeutic agents to tumoral lesions. Each bacterium can provide a significant thrust propulsion force generated by two flagella bundles exceeding 4pN. Furthermore, a chain of single-domain magnetosomes embedded in the cell allows computer directional control and tracking using a magnetic resonance...
This paper investigates the influence of the magnetosome's chain, the motility, and the bacterial cell of MC-1 magnetotactic bacteria (MTB) on the Magnetic Resonance imaging (MRI) contrast. Because of its embedded magnetic nanoparticles, that allow magnetic guidance and imaging contrast generation under MRI, magnetotactic bacteria are being considered for therapeutic drug delivery to tumors. In order...
The proposed Magnetotactic Bacteria (MTB) based bio-carrier has the potential to greatly improve pathogenic bacteria detection time, specificity, and sensitivity. Microbeads are attached to the MTB and are modified with a coating of an antibody or phage that is specific to the target pathogenic bacteria. Using magnetic fields, the modified MTB are swept through a solution and the target bacteria present...
Magnetotactic bacteria (MTB) can be controlled by an externally applied magnetic field. Their fast migration speed and quick response time, along with their capability to achieve 4 pN thrust force, make them well suited for micro-bio-actuators and bio-carriers. Here, we use conventional methods of microlithographyto construct a microfluidic device to evaluate the activity of MTB in microchannels....
The initial design of a 500 mumtimes200 mum untethered microrobot for future operations in an aqueous medium is briefly described. Electrical energy requirement is minimized by exploiting the motility of magnetotactic bacteria embedded in special reservoirs and used to propel the microrobot. An embedded control microcircuit powered through photovoltaic cells is developed to control the swimming directions...
Computer cell tracking using an optical microscope and an image-processing module has proven to be a valuable technique for the study of cell behavior such as motility and migration. Validation of these techniques is difficult and often done by manual analysis or with the aid of limited and case-specific simulation software. We have developed a general simulation system that returns optical microscope...
Summary form only given. The treatment of cancer is one of the most challenging tasks of modern medicine and secondary toxicity remains a critical issue. Although intra-arterial chemotherapy or chemo-embolization provides interesting success, the release of drug in the systemic circulation prevents high intra-tumoral drug concentration to be sustained. Hence, targeting specifically the tumor cells...
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