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There is a key problem that how brain uses the properties of synaptic dynamics to implement its macro-functions. The dynamic synapse model made by J. S. Liaw and T. W. Berger provided an example of implementing speech recognition function with dynamic synaptic mechanisms. The emergence mechanisms of recognition function in the dynamic synapse model are qualitatively analyzed in this paper. The nonlinear...
Dentate granule cells receive inputs from the entorhinal cortex as the "perforant path". There are two components of the perforant path: the lateral component (LPP) and the medial component (MPP). LPP and MPP convey different sensory modality information. It remains elusive as to how signals from different inputs interact and integrate at the granule cell level. We attempted to address this...
Dentate granule cells receive inputs from the entorhinal cortex as the "perforant path". There are two components of the perforant path: the lateral component (LPP) and the medial component (MPP). LPP and MPP convey different sensory modality information. It remains elusive as to how signals from different inputs interact and integrate at the granule cell level. We attempted to address this...
Dentate granule cells receive inputs from the entorhinal cortex as the "perforant path". There are two components of the perforant path: the lateral component(LPP) and the medial component(MPP). LPP and MPP convey different sensory modality information. It remains elusive as to how signals from different inputs interact and integrate at the granule cell level. We attempted to address this...
The effectiveness of tetraethylammonium (TEA) and high-frequency stimulation (HFS) in inducing long-term synaptic modification is compared in CA1 and dentate gyrus (DG) in vitro. High-frequency stimulation induces long-term potentiation (LTP) at synapses of both perforant path-DG granule cell and Schaffer collateral-CA1 pyramidal cell pathways. By contrast, TEA (25 mM) induces long-term depression...
An integrated approach has been developed to facilitate the coupling of computational and empirical neuroscience by employing methodologies of simulation and experimental studies to provide a common language for these two disciplines to communicate. The core of the simulation tools (EONS, Elementary Objects of Neural Systems) is an object-oriented library comprising of neural models, from networks,...
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