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The yeast INO80 chromatin remodeling complex plays essential roles in regulating DNA damage repair, replication, and promoter architecture. INO80’s role in these processes is likely related to its ability to slide nucleosomes, but the underlying mechanism is poorly understood. Here we use ensemble and single-molecule enzymology to study INO80-catalyzed nucleosome sliding. We find that the rate of...
There has been little research into how end-user programming environments can provide explanations that could fill a critical information gap for end-user debuggers - help with debugging strategy. To address this need, we designed and prototyped a video-based approach for explaining debugging strategy, and accompanied it with a text-only approach. We then conducted a qualitative empirical study with...
Although there have been a number of studies of end-user software development tasks, few of them have considered gender issues for real end-user developers in real-world environments for end-user programming. In order to be trusted, the results of such laboratory studies must always be re-evaluated with fewer controls, more closely reflecting real-world conditions. Therefore, the research question...
We have been working to uncover gender differences in the ways males and females problem solve in end-user programming situations, and have discovered differences in males' versus females' use of several debugging features. Still, because this line of investigation is new, knowing exactly what to look for is difficult and important information could escape our notice. We therefore decided to bring...
We use the term gender HCI (human-computer interaction) to refer to research into how software relates to gender differences. Our particular focus is on how gender-neutral software works, not on gender-oriented content. Specifically, we have concentrated on software aimed at supporting everyday users doing problem solving. Several of the hypotheses we developed in the first step of our investigative...
Emerging research has sought to bring effective debugging devices to end-user programmers. This research has largely focused on how well such devices bring genuine "functional" rewards to end users. However, emerging models of programming behavior indicate that another, often ignored, type of reward - perceivable rewards - can play an equally vital role in how well debugging devices serve...
A human-centric issue that has not been considered in the design of end-user programming environments is whether gender differences exist that are important to the design of these environments. Ignoring this issue would miss the opportunity of enhancing the effectiveness of end-user programmers by incorporating appropriate mechanisms to support gender-associated differences in decision making, learning,...
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