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Whilst spirometry is the most common test of pulmonary function in Duchenne muscular dystrophy (DMD), cine MRI of diaphragm motion may provide a more direct and sensitive measure of diaphragm dysfunction, especially in a setting of clinical trials. As part of an on-going, natural history study in non-ambulant DMD patients, cine MRI of diaphragm motion is investigated as a potential objective biomarker...
Outcome measures in Duchenne muscular dystrophy (DMD) currently rely on invasive or functional but not very sensitive tests. Muscle MRI could offer a valuable alternative. A reliable evaluation of the upper limb could permit inclusion of non-ambulant DMD individuals not able to perform functional tests such as the 6-min walk test. 16 DMD boys and 10 age gender and age matched controls were included...
Atherosclerosis, the precursor to acute events such as myocardial infarction and stroke, is a focal inflammatory disease that is influenced by local hemodynamic forces such as wall shear stress (WSS). Phase contrast (PC) MRI is an established method that encodes blood velocity into the phase of an image. A requisite step for the calculation of WSS from PC-MRI data is delineation of the vasculature...
Quantitative first-pass magnetic resonance (MR) imaging studies assist in characterizing the severity of ischemic heart disease. Cardiac motion due to a patient's difficulty in maintaining the required breath hold is often severe, making registration necessary. In this paper we present a novel automatic affine registration algorithm. The algorithm utilizes an affine active contour to determine affine...
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