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This first‐in‐human, phase I study evaluated the safety, tolerability, pharmacokinetic and pharmacodynamic profile of ASKP1240 in healthy subjects. Twelve sequential groups (each 6 active and 3 placebo) were randomly assigned to placebo or single ascending doses of intravenous ASKP1240 (0.00003–10 mg/kg). ASKP1240 exhibited nonlinear pharmacokinetics, with mean maximal serum concentrations and area...
In response to the shortening product life cycle, we have increased parallelism in all aspects of our work in the microelectronics industry. In order to produce an integrated solution, management has increased the emphasis on teams. As an example, building-in reliability (BIR) during new product development and manufacturing in the semiconductor industry requires teams of technologists from design,...
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