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Introduction
During atrial fibrillation ablation (AFA), achievement of first pass isolation (FPI) reflects effective lesion formation and predicts long‐term freedom from arrhythmia recurrence. We aim to determine the clinical and procedural predictors of pulmonary vein FPI.
Methods
We reviewed AFA procedures in a multicenter prospective registry of AFA (REAL‐AF). A multivariate ordinal logistic...
In this paper, we introduce a hybrid free-space optics/radio frequency (FSO/RF) networking paradigm for mobile robot teams. We believe that such a model will emerge as a consequence of inherent limitations of RF based approaches. FSO technology has the potential to provide tremendous increases in per-node throughput for a mobile ad-hoc network (MANET). To motivate this paradigm, we first provide a...
Enterprise Architecture Principles (EAPs) are regarded as a pivotal element in the definition of Enterprise Architecture (EA). However, the EA discipline still suffers from some fundamental limitations, such as the lack of guidelines for developing a generic set of principles and a theoretical basis for developing them. Assuming enterprises as viable systems, this paper suggests a set of design principles...
Ubiquitin‐specific protease 33 (USP33) is a deubiquitinase that has been associated with a variety of physiological events. Here, we show the existence of multiple USP33 splice variants and characterize the sub‐cellular localization of endogenous USP33 as well as GFP‐USP33 isoforms 1–3. The localization of USP33 is broadly confined to the secretory pathway, with all variants localizing to endoplasmic reticulum‐associated structures. In addition, GFP‐USP33 variant 3 shows a marked accumulation at the Golgi apparatus. Several deubiquitinases have large insertions within their otherwise highly conserved catalytic domains, the function of which is poorly characterized. Analysis of USP33 reveals a role for two distinct inserts within the catalytic domain. One is required for association with the endoplasmic reticulum, whilst the second is required for membrane association, but can be alternatively spliced (variant 3) to excise eight amino acids, which otherwise suppress Golgi localization. We propose that varying the expression of differentially localized isoforms provides a means to influence the spectrum of substrates encountered by USP33.
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