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2,6-Diaminopurine(DAP)-resistants mutants have been isolated from mouse lymphoma 5178Y TK + /TK - heterozygotes. In the presence of 50 μM DAP, two colony types were isolated. Small colonies contained 50% wild-type adenine phosphoribosyl transferase (APRT) activity (partial mutants), whereas large colonies have undetectable levels of APRT (aprt - mutants). aprt - mutants...