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Tenascin (TN) is a glycoprotein of the extracellular matrix. In normal colon mucosa TN occurs in low concentrations. Inflammatory and neoplastic diseases show TN increase. We studied sera of patients with benign neoplasias (familial polyposis) and of patients with colorectal carcinoma by a double-sided-sandwich ELISA.nTN (mean ± SD)Normal controls513.2±1.7μg/mlFamilial polyposis173.9±2.4μg/mlColorectal...
From a panel of 4 murine monoclonal antibodies directed against keratin 19 various antibody combinations were evaluated in solid-phase enzyme-linked sandwich immunoassays for detection of soluble keratin 19 fragments in patient sera. One of these antibody combinations, comprised of the monoclonal antibodies Ks 19.1 and BM 19.21, was selected for further development to a routine test (Enzymun-Test...
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