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TRPM4 is a Ca 2+ -activated non-selective cation (CAN) channel that functions in cell depolarization, which is important for Ca 2+ influx and insulin secretion in pancreatic β-cells. We investigated TRPM4 expression and function in the β-cell lines HIT-T15 (hamster), RINm5F (rat), β-TC3 (mouse), MIN-6 (mouse) and the α-cell line INR1G9 (hamster). By RT-PCR, we identified TRPM4 transcripts...
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