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The behaviour of four local anaesthetics (lidocaine, levobupivacaine, ropivacaine and tetracaine) and one general anaesthetic (propofol) is compared when interacting with two types of model membranes: supported layers of liposomes and liposomes in solution. Several liposomal compositions were tested: dimyristoylphosphatidylcholine (DMPC), binary mixtures of DMPC with cholesterol (CHOL), and ternary...
Supported layers of vesicles of dimyristoyl and dipalmitoyl phosphatidylcholine containing cholesterol are adequate models for eukaryotic plasma membranes. In this work it was investigated the adsorption of unilamellar vesicles on the surface of oxidized gold, using a QCM-D, AFM and LSCFM. The results of all techniques indicate that a dense layer of intact liposomes irreversibly adsorbs on the gold...
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