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Effects of systemic and local administration of prazosin, an α 1 -adrenoceptor antagonist, on dopaminergic neurotransmission in the caudate putamen and nucleus accumbens were characterized in microdialysis experiments. Prazosin (10 mg/kg s.c.) resulted in blood pressure reduction, however, did not alter dopamine release in the two examined brain areas. In contrast, local administration of...
Porcine transforming growth factor 1 and 2 (pTGF-β1 and -β2) and milk growth factor (MGF) at 1 ng/ml significantly inhibited the proliferation of human lymphocytes induced by anti-CD3 antibodies. In contrast, the anti-CD3-mediated increase of intracellular Ca 2+ and the activation and translocation of protein kinase C were not affected by the transforming growth factors.
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