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This study evaluated the effects of oral capecitabine on the quality of life (QOL) of Brazilian patients with metastatic colorectal cancer who received capecitabine (1000 or 1250 mg/m 2 twice a day on days 1-14, every 3 weeks) in a prospective, multicenter, open-label, noncomparative study. Patients completed the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-CR38...
Wilmen, A., B. Van Eyll, B. GÖKe and R. GÖKe. Five out of six tryptophan residues in the N-terminal extracellular domain of the rat Glp-1 receptor are essential for its ability to bind Glp-1. Peptides 18(2) 301–305, 1997.—Oligonucleotide-directed mutagenesis was utilized to investigate the requirement of tryptophan residues located in the N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor...
The proglucagon-derived glucagon-like peptide-1 (GLP-1) secreted by the L-cells exerts an insulinotropic effect at pancreatic β-cells. The GLP-1 receptor belongs to a new subfamily of the superfamily of seven transmembrane, G-protein-coupled receptors (7 TM receptors). We show that a single point mutation within a nonconserved motif of the N-terminal, extracellular domain of the GLP-1 receptor results...
GLP-1 (glucagon-like peptide 1 (7-36) amide) plays an important role in the regulation of insulin secretion and proinsulin gene expression of pancreatic β-cells. Patients with insulinoma tumors show uncontrolled insulin hypersecretion. This study demonstrates the molecular cloning of a cDNA for the GLP-1 receptor from a human insulinoma employing a λ-gt 11 cDNA library. The cloned cDNA encoded a seven...
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