Search results for: Motoharu Awazawa

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article

Acquired partial lipoatrophy as graft-versus-host disease and treatment with metreleptin: two case reports

Yusuke Shibata, Atsuko Nakatsuka, Jun Eguchi, Satoshi Miyamoto, more

Journal of Medical Case Reports > 2018 > 12 > 1 > 1-5

Introduction Acquired partial lipoatrophy has been reported after bone marrow transplantation during childhood; however, no adult cases have previously been reported. We herein report two adult cases of acquired partial lipoatrophy after transplantation. Case presentation A 28-year-old Japanese woman developed diabetic ketoacidosis and received insulin therapy after bone marrow transplantation....

article

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding

Merly C. Vogt, Lars Paeger, Simon Hess, Sophie M. Steculorum, more

Cell > 2014 > 156 > 3 > 495-509

Maternal metabolic homeostasis exerts long-term effects on the offspring’s health outcomes. Here, we demonstrate that maternal high-fat diet (HFD) feeding during lactation predisposes the offspring for obesity and impaired glucose homeostasis in mice, which is associated with an impairment of the hypothalamic melanocortin circuitry. Whereas the number and neuropeptide expression of anorexigenic proopiomelanocortin...

article

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

Motoharu Awazawa, Kohjiro Ueki, Kazunori Inabe, Toshimasa Yamauchi, more

Cell Metabolism > 2011 > 13 > 4 > 401-412

Insulin resistance is often associated with impeded insulin signaling due either to decreased concentrations or functional modifications of crucial signaling molecules including insulin receptor substrates (IRS) in the liver. Many actions of adiponectin, a well-recognized antidiabetic adipokine, are currently attributed to the activation of two critical molecules downstream of AdipoR1 and R2: AMP-activated...

article

Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

Kazuma Kaneko, Kohjiro Ueki, Noriko Takahashi, Shinji Hashimoto, more

Cell Metabolism > 2010 > 12 > 6 > 619-632

Type 2 diabetes is characterized by insulin resistance and pancreatic β cell dysfunction, the latter possibly caused by a defect in insulin signaling in β cells. Inhibition of class IA phosphatidylinositol 3-kinase (PI3K), using a mouse model lacking the pik3r1 gene specifically in β cells and the pik3r2 gene systemically (βDKO mouse), results in glucose intolerance and reduced insulin secretion in...

article

Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway

Motoharu Awazawa, Kohjiro Ueki, Kazunori Inabe, Toshimasa Yamauchi, more

Biochemical and Biophysical Research Communications > 2009 > 382 > 1 > 51-56

Adiponectin, one of the insulin-sensitizing adipokines, has been shown to activate fatty acid oxidation in liver and skeletal muscle, thus maintaining insulin sensitivity. However, the precise roles of adiponectin in fatty acid synthesis are poorly understood. Here we show that adiponectin administration acutely suppresses expression of sterol regulatory element-binding protein (SREBP) 1c, the master...

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Search results for: Motoharu Awazawa

Acquired partial lipoatrophy as graft-versus-host disease and treatment with metreleptin: two case reports

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway

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INFONA - science communication portal

Search results for: Motoharu Awazawa

Acquired partial lipoatrophy as graft-versus-host disease and treatment with metreleptin: two case reports

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway

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