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Lsc-homology domains are found in several eukaryotic nucleotide exchange factors which act on Rho-family GTPases. They show limited amino acid sequence similarity to RGS proteins, which down-regulate the cellular signaling by the α-subunits of trimeric G-proteins and have been shown to interact with Gα12 and Gα13. It is believed that the RGS-like (RGSL) domain constitutes the functional link between...