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Purpose Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with neurocognitive impairment. We examined the role of the systemic inflammatory response, measured by high-sensitivity C-reactive protein (hsCRP) assay, and the effect of CPAP treatment on hsCRP and cognitive impairment in patients with OSAHS. Methods Eligible subjects (n = 178) were categorized into two groups: absent or...
A total synthesis of Koninginin A and its diastereoisomer starting from L-(+) tartaric acid is described. The key steps involved the Pd catalyzed cross-coupling of alkylboron with vinyl triflate and the 1 O 2 addition to diene. This study not only corrected the relative configuration of Koninginin A, but also assigned its absolute configuration as 1S, 4R, 5S, 6S, 9S, 10S.
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