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The cellular prion protein (PrP C ) is a membrane-bound glycoprotein abundantly expressed in neurons and glial cells within the CNS. The scrapie prion protein (PrP Sc ) is a conformationally altered isoform of PrP C that is responsible for prion diseases, also termed transmissible spongiform encephalopathies (TSE), a group of neurodegenerative diseases that affect a wide variety...
The cellular prion protein (PrP C ) is a membrane-bound glycoprotein mainly present in the CNS. The scrapie prion protein (PrP Sc ) is an isoform of PrP C , and it is responsible for transmissible spongiform encephalopathies (TSEs), a group of neurodegenerative diseases affecting both humans and animals. The presence of the cellular form is necessary for the establishment and...
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