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We report the application of a cell-based assay (CBA) using NG108-15 a hybridoma cell strain and a protein phosphatase inhibition-based assay (PPIA) as alternative toxicological or functional semiquantitative tools, respectively, for the screening of lipophilic toxins in mussels (Mytilus galloprovincialis). Acetonic extracts were directly tested by CBA and PPIA but severe matrix effects were observed...
New advances in the use of NG108-15 cells for marine toxins detection and quantification are presented. We have established modifications on ouabain and veratridine proportion to obtain good toxins dose-response curves on this cell line for neurotoxins acting on voltage gated sodium channel (VGSC). Interesting, differences in the toxic response were observed between two VGSC activating toxins, brevetoxin-3...
The suitability and sensitivity of two neural cell models, NG108-15 and Neuro-2a, to different marine toxins were evaluated under different incubation and exposure times and in the presence or absence of ouabain and veratridine (O/V).NG108-15 cells were more sensitive to pectenotoxin-2 than Neuro-2a cells. For saxitoxin, brevetoxin-3, palytoxin, okadaic acid and dinophysistoxin-1 both cell types proved...
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