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Clozapine (Clozaril /Leponex ) is the treatment of choice for therapy-resistant schizophrenia. Mortality rates in patients with schizophrenia are approximately double those of the general population. To determine the drug's effect on mortality, we compared rates of various causes of death in 67 072 current and former clozapine users, identified from the Clozaril National Registry. Deaths occurring...
This study evaluated the incidence rates of peptic ulcer disease (PUD) and upper gastrointestinal hemorrhage (GIB) in 68,028 people younger than 65 years, and who used diclofenac sodium, naproxen, piroxicam, or sulindac. The patients were all members of health maintenance organizations. Data were acquired in a retrospective manor by review of all claims related to either inpatient or outpatient treatment,...
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