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Chronic allograft nephropathy (CAN) is a complex process of alloimmune responses and chronic inflammation leading to fibrosis and vasculopathy. We examined the biological role of proinflammatory vascular endothelial growth factor (VEGF) in a rat renal transplantation model of CAN.Syngraft and allograft recipients were treated with a suboptimal dose of cyclosporine A which allows acute rejection and...