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Fertilization in mammals stimulates a series of Ca2+ oscillations that continue for 3–4 h. Cell-cycle-dependent changes in the ability to release Ca2+ are one mechanism that leads to the inhibition of Ca2+ transients after fertilization. The downregulation of InsP3Rs at fertilization may be an additional mechanism for inhibiting Ca2+ transients. In the present study we examine the mechanism of this...
A fertilization-induced increase in intracellular Ca 2+ is responsible for initiating all of the events of egg activation. In mammals, the Ca 2+ increase takes the form of a series of Ca 2+ oscillations showing complex temporal and spatial properties. To understand the nature of these changes, we have investigated the expression patterns of the three isoforms of the inositol...
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