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HMG-CoA reductase and ACAT are associated with regulation of cholesterol metabolism. In present study, the deglycosylated form of hesperidin, hesperetin, was tested both in vivo and in vitro to examine potential differences in mechanism through which hesperetin might affect cholesterol metabolism. When tested in vitro, hesperetin had no inhibitory effect on either HMG-CoA reductase or ACAT. Male...