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Alzheimer's disease (AD) is a neurodegenerative condition involving accumulation of the β-amyloid peptide, Aβ 1–42 . Previously we have shown that amyloid peptides (Aβ 1–42 , Aβ 1–40 ) have different actions on the three major brain nicotinic acetylcholine receptor (nAChR) subtypes (α7, α4β2 and α3β4). The methionine in position 35 of Aβ (M35) has been shown to be important...