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The recent identification of stem cell pools in a variety of unexpected tissue sources has raised the possibility that a pluripotent stem cell population may reside in the myocardium and contribute to the post-natal growth of this tissue. Here, we demonstrate that the post-natal myocardium contains a resident verapamil-sensitive side population (SP), with stem cell-like activity. When growth of the...
Duchenne Muscular Dystrophy (DMD) originates from deleterious mutations in the dystrophin gene, with a complete loss of the protein product . Subsequently, the disease is manifested in severe striated muscle wasting and death in early adulthood . Dystrophin provides a structural base for the assembly of an integral membrane protein complex . As such, dystrophin deficiency leads to an altered mechanical...
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