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After more than twenty years of use Good Laboratory Practice, or GLP, has attained a secure place in the world of testing chemicals and other “test items” with regard to their safety for humans and the environment. Gone are the days when the GLP regulations were hotly debated amongst scientists in academia and industry and were accused of stifling flexibility in, imaginative approaches to, and science-based...
Therapeutic agents, active substances as well as metabolites, have been detected in the environment, notably in the aquatic compartment. Such contamination may induce adverse environmental effects, and the question is, whether respective hazards could be deduced from their pharmacodynamic properties and activities, and whether there could indeed be relevant risks at the (very low) environmental concentrations...
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