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Induction of mutation and micronucleus (MN) formation by nitric oxide (NO) was investigated in mammalian cells using sodium nitroprusside (SNP) as a drug donor of NO. Results showed that the concentration of NO 2− in the tested solution rose according to time- and concentration-exposure to SNP. The treatment of SNP (0.5–8 μmol/ml with S9 or 2–8 μmol/ml without S9) induced a concentration-dependent...