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The relationship between transforming growth factor α (TGFα)-induced cell proliferation and prostaglandin synthesis was investigated using growth-arrested human keratinocytes of the HaCaT line. Depending on the TGFα concentration, the stimulation of DNA synthesis (5-fold) was found to be either insensitive (at ≤ 10 ng/ml TGFα) or sensitive (at ≥ 20 ng/ml TGFα) to inhibition by both indomethacin,...