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MicroRNA-155 (miR-155) is highly expressed in many cancers such as B cell lymphomas and myeloid leukemia, and inflammatory disorders such as rheumatoid arthritis, atopic dermatitis and multiple sclerosis. The role of miR-155 as both a promoter of inflammation and an oncogenic agent provides a clear need for miR-155 itself to be stringently regulated. We have recently found that the immunomodulatory...
IL10 is a pluripotent cytokine that has multiple functions on cells of the immune system. In most cases, IL10 acts as an anti-inflammatory cytokine, dampening the inflammatory response by down-regulating a subset of pro-inflammatory genes induced by TLR signalling. In B cells, IL10 appears to have an additional role enhancing proliferation, differentiation and class-switch recombination required for...
Polyunsaturated fatty acids (PUFA) can modulate the immune response, however the mechanism by which they exert this effect remains unclear. Previous studies have clearly demonstrated that the cis-9, trans-11 isomer of conjugated linoleic acid (c9,t11-CLA), found predominantly in beef and dairy products, can modulate the response of immune cells to the toll-like receptor (TLR) 4 ligand, lipopolysaccharide...
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