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We have recently shown that unloaded cardiac myocytes, from the remote non-infarcted, hypocontractile regions of remodeled rat hearts, contract normally. Since load is an important determinant of contractile response, we investigated the effects of viscous loading on the contractile function (video edge detection) of 268 myocytes isolated from the remodeled myocardium of infarcted (MI) rat hearts,...
Background: We have shown that myocytes isolated from the regionally dysfunctional hypocontractile segment of non-infarcted LV from post-MI remodeled rat hearts exhibit normal contractile function and [Ca ++ ]i kinetics. To identify whether increasing frequency of stimulation would unmask any latent myocyte dysfunction, we examined myocyte shortening (video edge detection) and [Ca ...
Ventricular remodeling is a key event in the evolution of congestive heart failure following a myocardial infarction (MI). We have recently shown that although remodeled hearts are dysfunctional at the global level, cardiomyocytes isolated from their remote, non-infarcted, hypocontractile segments show no contractile abnormalities both in the basal state and during inotropic stimulation with [Ca...