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J. Neurochem. (2009) 112, 963–971.
AbstractDopamine acts through a family of G protein‐coupled receptors to exert its myriad effects. The D3 Dopamine receptor is one member of the D2‐like dopamine receptors. We have previously demonstrated in human embryonic kidney (HEK293) cells that D3 receptor stimulation of phospholipase D (PLD) activity is pertussis toxin insensitive [Everett and Senogles. Neurosci. Lett....
Within the dopamine receptor family, the D 3 dopamine receptor's function remains inadequately described. The D 3 receptor has been shown to couple to inhibition of adenylyl cyclase, stimulation of mitogenesis, and regulation of K + and Ca 2+ currents, all in a pertussis toxin (PTX)-sensitive manner. Here we report D 3 receptor activation of the phospholipase...
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