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Our cells are continuously exposed to oxidative stress which produces oxidative lesions in DNA. These lesions are recognized and removed by glycosylases. NEIL1 glycosylase is present in mammalian cells that possess unique characteristic of removing lesions from wide type of structures like dsDNA, ssDNA, interstrand crosslinks, bubbles and bulges. Impairment in its activity severely affects the repair...
Several reports suggest that non-synonymous single nucleotide polymorphisms affect the function of XRCC1 which impairs DNA repair capacity and thus increases risk to diseases like cancer. In our study, we predicted the most damaging nsSNPs using a computational approach and analysed its functional impact on the XRCC1 and LIG3 interaction. SNP rs2307166 was predicted to be deleterious using eight software...
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