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Cell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV. We targeted the SIV CCR5 coreceptor in a combined CCR5–SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV...
At present, heterosexual transmission accounts for up to 90% of new HIV infections worldwide. Therefore, it is of global importance to develop strategies to combat further spread of the epidemic via this route. Prophylactic treatment with antiviral drugs before or shortly after mucosal exposure may limit virus infection to the mucosa and the draining lymph nodes and/or may reduce virus load such...
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