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Neocortical networks play a major role in the genesis of generalized spike-and-wave (SW) discharges associated with absence seizures in humans and in animal models, including genetically predisposed WAG/Rij rats. Here, we tested the hypothesis that alterations in GABA B receptors contribute to neocortical hyperexcitability in these animals. By using Real-Time PCR we found that mRNA levels...
Fragile X syndrome is an inherited cause of mental retardation. We used extra- and intracellular recordings in brain slices obtained from wild type and fragile X knockout mice to establish whether bath application of the cholinergic agent carbachol (5 μM) induces different responses in neurons of the subiculum, a limbic structure involved in learning and memory. We found that carbachol diminished...
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