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Perform a comparison of results obtained with a LC-MS/MS method and a Remedi® instrument on clinical serum samples.Results obtained on 146 selected plasma samples were compared between the two methods.On the 336 positive identifications, 89% were obtained using the LC-MS/MS technique and 57% by the LC-DAD. Benzodiazepines were well recognized by LC-MS/MS. For some compounds such as antidepressant...
Evaluate a new LC–MS/MS screening method for drugs and drugs of abuse as an alternative to the existing methods used in clinical toxicology laboratories.The work was divided in two parts. The first part was dedicated to the technical development and evaluation of the method for which a set of 97 drugs and relevant metabolites was used to perform a complete investigation of matrix effects and lower...
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