Search results for: Soliman Mohammadi-Samani

Items from 1 to 20 out of 30 results

article

Targeted co‐delivery of paclitaxel and anti P‐gp shRNA by low molecular weight PEI decorated with L‐3,4‐dihydroxyphenylalanine

Maryam Kazemi, Elahehnaz Parhizkar, Soliman Mohammadi Samani, Omidreza Firuzi, more

Biotechnology Progress > 39 > 2 > n/a - n/a

Co‐delivery of small chemotherapeutic molecules and nucleic acid materials via targeted carriers has attracted great attention for treatment of resistant tumors and reducing adverse effects. In this study, a targeted carrier for co‐delivery was prepared based on low‐molecular weight polyethylenimine (LMW PEI). Paclitaxel (PTX) was covalently conjugated onto PEI via a succinate linker. The PEI conjugate...

article

Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5‐fluorouracil

Fatemeh Farjadian, Maryam Moghadam, Mohammad Monfared, Soliman Mohammadi‐Samani

AIChE Journal > 68 > 12 > n/a - n/a

In this study, amino‐functionalized mesoporous silica (MS) particles were synthesized and loaded with the anticancer drug, 5‐Fu. In a post‐modification reaction, the pores were gated by an azobenzene derivative to act as an enzyme‐responsive drug delivery system. The synthesis and characterization of the MS structure were validated using various instrumental techniques such as XRD, N₂ adsorption/desorption,...

article

Nose‐to‐brain delivery of sumatriptan‐loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation

Moein Masjedi, Amir Azadi, Reza Heidari, Soliman Mohammadi‐Samani

Journal of Pharmacy and Pharmacology > 72 > 10 > 1341 - 1351

Objectives Migraine is a neurological disorder with unilateral pulsatile headache which can affect the functions of sufferers. Migraineurs experience some undesirable symptoms such as pain, nausea, vomiting and in some cases auras which make the oral delivery non‐selective. The lipid nanoparticles are considered as good carriers for nose‐to‐brain drug delivery. The present study aimed to formulate...

article

Controlled-release in-situ gel forming formulation of tramadol containing chitosan-based pro-nanogels

Maedeh Barati, Soliman Mohammadi Samani, Leila Pourtalebi Jahromi, Hajar Ashrafi, more

International Journal of Biological Macromolecules > 2018 > 118 > PB > 1449-1454

Chronic pain is one of the most prevalent health problems worldwide. Tramadol is a synthetic semi-opioid analgesic, interacting with serotonergic, adrenergic and opioid receptors to reduce the pain but its short half-life in vivo may reduce patient compliance in case of chronic pains. To overcome this problem, novel drug delivery systems have been investigated. This study focuses on a chitosan based...

article

Synthesis and in vitro assessment of novel water‐soluble dextran‐docetaxel conjugates as potential pH sensitive system for tumor‐targeted delivery

Elahehnaz Parhizkar, Saeid Daneshamouz, Soliman Mohammadi‐Samani, Amirhossein Sakhteman, more

Journal of Applied Polymer Science > 134 > 43 > n/a - n/a

Docetaxel is a potent taxane agent mostly used in breast, lung, and prostate cancers. Its low water solubility is the major drawback that leads to use of Tween 80 as surfactant and ethanol as solvent in market formulation. But, these excipients cause severe hypersensitivity reactions. In this study, docetaxel was conjugated to biocompatible polymer, dextran 70 kDa, via a pH sensitive linker to enhance...

article

In vitro and in vivo assessment of EDTA-modified silica nano-spheres with supreme capacity of iron capture as a novel antidote agent

Fatemeh Farjadian, Sahar Ghasemi, Reza Heidari, Soliman Mohammadi-Samani

Nanomedicine: Nanotechnology, Biology and Medicine > 2017 > 13 > 2 > 745-753

Mesoporous silica nanoparticles having structure of MCM-41 category with amine and EDTA functional groups in the pores were prepared using a co-condensation reaction. The synthetic steps eventuated in the mesoporous silica nanoparticles with spherical sizes lower than 50nm supposed to have high surface area. The nanoparticles' structure and functionality were characterized by FTIR spectroscopy and...

article

Data on cell growth inhibition induced by anti-VEGF siRNA delivered by Stealth liposomes incorporating G2 PAMAM-cholesterol versus Metafectene® as a function of exposure time and siRNA concentration

Nasim Golkar, Soliman Mohammadi Samani, Ali Mohammad Tamaddon

Data in Brief > 2016 > 8 > C > 1018-1023

In this data article, carboxyfluorescein-loaded liposomes were prepared and purified from free carboxyfluorescein using gel filtration chromatography in the first part. In the next part, following preparation of anti-VEGF siRNA loaded liposomes incorporating hydrophobically modified G2 PAMAM dendrimer (G2-Chol_40%) (Golkar et al., 2016) [1], the cell growth inhibition induced by the formulations (siRNA/Metafectene...

article

Modulated cellular delivery of anti-VEGF siRNA (bevasiranib) by incorporating supramolecular assemblies of hydrophobically modified polyamidoamine dendrimer in stealth liposomes

Nasim Golkar, Soliman Mohammadi Samani, Ali Mohammad Tamaddon

International Journal of Pharmaceutics > 2016 > 510 > 1 > 30-41

A novel lipopolymer based system was designed and characterized for cellular delivery of anti-VEGF siRNA in SKBR-3 breast tumor cell line. Polyamidoamine (PAMAM) dendrimers of low generations (G1, G2 and G3) were incorporated into polyethylene glycol (PEG)-stabilized liposomes by following the consecutive steps: (a) synthesis of the cholesterol conjugates (40% molar ratio of cholesterol to primary...

article

Hydroxyl-modified magnetite nanoparticles as novel carrier for delivery of methotrexate

Fatemeh Farjadian, Sahar Ghasemi, Soliman Mohammadi-Samani

International Journal of Pharmaceutics > 2016 > 504 > 1-2 > 110-116

In this work, novel hydroxyl-modified magnetite nanocarriers are introduced as efficient host for methotrexate conjugation. The modification was based on the Micheal type addition reaction between tris(hydroxymethyl) aminomethane and acrylamidopropyl functionalized, silica-coated magnetite nanoparticle. The chemical structure characterization was carried out by FT-IR and the organic content was determined...

article

Design, preparation, and in vitro characterization of a trimodally-targeted nanomagnetic onco-theranostic system for cancer diagnosis and therapy

Abdolhossein Zarrin, Somayeh Sadighian, Kobra Rostamizadeh, Omidreza Firuzi, more

International Journal of Pharmaceutics > 2016 > 500 > 1-2 > 62-76

In this study, the aim was to introduce and characterize a new trimodally-targeted nanomagnetic onco-theranostic system for simultaneous early diagnosis and efficient treatment of cancer. The onco-theranostic system was designed as it could target the tumor site through three targeting approach, i.e. magnetic, folic acid receptor, and pH sensitivity, and concurrently, due to the presence of superparamagnetic...

article

Effects of phosphate supplementation on Pseudomonas aeruginosa invasive behavior in burn wound infections: A simple approach to a big problem

Soliman Mohammadi-Samani, Shahriyar Kouroshfard, Negar Azarpira

Burns > 2016 > 42 > 2 > 428-433

This study was designed to investigate the effect of inorganic phosphate supplementation on invasive behavior of Pseudomonas aeruginosa in burn wound infections. An emulsion-based lotion containing sodium dihydrogen phosphate was formulated and then 50 female Sprague-Dawley rats with burn wounds were used to assess the effect of phosphate supplementation on swarming motility of P. aeruginosa. On the...

article

Trachyspermum ammi 10 % topical cream versus placebo on neuropathic pain, a randomized, double-blind, placebo-controlled trial

Peyman Petramfar, Mahmoodreza Moein, Soliman Mohammadi Samani, Sayed Hamidreza Tabatabaei, more

Neurological Sciences > 2016 > 37 > 9 > 1449-1455

A four-week, double-blind, randomized, placebo-controlled trial was conducted to assay the effectiveness of Ajwain 10 % (Trachyspermum ammi Sprague) topical cream on neuropathic pain. Intervention encompassed Ajwain 10 % and placebo creams. Ninety-two patients who specifically mentioned daily and nocturnal burning feet were randomly assigned to receive one of those interventions. Presence and decline...

article

Cholesterol-conjugated supramolecular assemblies of low generations polyamidoamine dendrimers for enhanced EGFP plasmid DNA transfection

Nasim Golkar, Soliman Mohammadi Samani, Ali Mohammad Tamaddon

Journal of Nanoparticle Research > 2016 > 18 > 5 > 1-20

Aimed to prepare an enhanced gene delivery system with low cytotoxicity and high transfection efficiency, various cholesterol-conjugated derivates of low generation polyamidoamine (PAMAM) dendrimers were prepared. The conjugates were characterized by TNBS assay, FTIR, and ¹H-NMR spectroscopy. Self-assembly of the dendrimer conjugates (G1-Chol, G2-Chol, and G3-Chol) was investigated by pyrene assay...

article

Design and cell cytotoxicity assessment of palmitoylated polyethylene glycol‐grafted chitosan as nanomicelle carrier for paclitaxel

Sahar Abbasi, Gholamhossein Yousefi, Omidreza Firuzi, Soliman Mohammadi‐Samani

Journal of Applied Polymer Science > 133 > 13 > n/a - n/a

Amphiphilic graft copolymers were synthesized using chitosan with varying substitution degrees of methoxy polyethylene glycol and palmitic acid. FT‐IR, ¹H‐NMR, differential scanning calorimetry, and elemental analysis showed successful chitosan modification. Amphiphilic copolymers are able to produce nano ssemblies with low critical micelle concentration (CMC). It was demonstrated that particle size...

article

Effects of Quince syrup on clinical symptoms of children with symptomatic gastroesophageal reflux disease: A double-blind randomized controlled clinical trial

Mohammad Ebrahim Zohalinezhad, Mohammad Hadi Imanieh, Soliman Mohammadi Samani, Abdolali Mohagheghzadeh, more

Complementary Therapies in Clinical Practice > 2015 > 21 > 4 > 268-276

The aim of this study was to evaluate the efficacy of Quince syrup in pediatrics with symptomatic gastroesophageal reflux disease (GERD).Participants (n = 80) were randomly assigned to the Quince group (0.6 cc/kg/day) or the Omeprazole group (1 cc/kg/day). Age specific questionnaires were used to assess the frequency and severity of the GERD symptoms. Mean of cumulative symptom score (CSS) at weeks...

article

Controlled size synthesis and application of nanosphere MCM-41 as potent adsorber of drugs: A novel approach to new antidote agent for intoxication

Fatemeh Farjadian, Parisa Ahmadpour, Soliman Mohammadi Samani, Majid Hosseini

Microporous and Mesoporous Materials > 2015 > 213 > C > 30-39

By using a co-condensation method, mesoporous silica nanoparticles (MSNs) of three different varieties with a MCM-41 pattern of structures containing functional groups inside the pores were prepared. The synthetic structure resulted in formation of highly dispersed MSNs without precipitation. The surface areas along with the pore size distribution were examined using nitrogen adsorption and desorption...

article

A Comparison between the Nephrotoxic Profile of Gentamicin and Gentamicin Nanoparticles in Mice

Akram Jamshidzadeh, Reza Heidari, Soliman Mohammadi‐Samani, Negar Azarpira, more

Journal of Biochemical and Molecular Toxicology > 29 > 2 > 57 - 62

Aminoglycoside antibiotics are widely used against Gram‐negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosides, finding new therapeutic strategies against this problem has a great clinical...

article

Randomized and double-blinded clinical trial of the safety and calcium kidney stone dissolving efficacy of Lapis judaicus

Pouya Faridi, Hassan Seradj, Soliman Mohammadi-Samani, Mehrdad Vossoughi, more

Journal of Ethnopharmacology > 2014 > 156 > Complete > 82-87

Kidney stones are one of the most common disorders of the urinary tract and cause a great deal of morbidity and economic loss. Because of the side effects and costs of current interventional procedures, researchers are interested in finding medicinal therapies. In this regard, some reports have focused on traditional medicines as a drug discovery resource. Iranian scholars in the medieval era recommended...

article

Hydatid cyst formation in male Balb/c mice following the intraperitoneal injection of live protoscoleces and activated oncospheres: a comparative study

Sara Ahmadnia, Mohammad Moazeni, Soliman Mohammadi-Samani, Amir Mootabi Alavi

Journal of Parasitic Diseases > 2014 > 38 > 1 > 77-80

This study was designed to evaluate and compare the infection rate and cyst formation in male Balb/c mice following intraperitoneal injection of protoscoleces and activated oncospheres. Protoscoleces were collected aseptically from the liver of naturally infected sheep. The eggs were obtained from three experimentally infected dogs and activated oncospheres were prepared as described by Heath and...

article

Nanostructure l-asparaginase-fatty acid bioconjugate: Synthesis, preformulation study and biological assessment

Hajar Ashrafi, Mohsen Amini, Soliman Mohammadi-Samani, Younes Ghasemi, more

International Journal of Biological Macromolecules > 2013 > 62 > Complete > 180-187

The present study aims to develop a novel l-asparaginase fatty acid bioconjugates and characterize their applicability for intravenous delivery of l-asparaginase. These bioconjugates were achieved by covalent linkage of fatty acids having different chain lengths (C ₁₂ , C ₁₆ and C ₂₂ ) to the native enzyme. To determine the optimum conditions of bioconjugation, the effect of...

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INFONA - science communication portal

Search results for: Soliman Mohammadi-Samani

Targeted co‐delivery of paclitaxel and anti P‐gp shRNA by low molecular weight PEI decorated with L‐3,4‐dihydroxyphenylalanine

Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5‐fluorouracil

Nose‐to‐brain delivery of sumatriptan‐loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation

Controlled-release in-situ gel forming formulation of tramadol containing chitosan-based pro-nanogels

Synthesis and in vitro assessment of novel water‐soluble dextran‐docetaxel conjugates as potential pH sensitive system for tumor‐targeted delivery

In vitro and in vivo assessment of EDTA-modified silica nano-spheres with supreme capacity of iron capture as a novel antidote agent

Data on cell growth inhibition induced by anti-VEGF siRNA delivered by Stealth liposomes incorporating G2 PAMAM-cholesterol versus Metafectene® as a function of exposure time and siRNA concentration

Modulated cellular delivery of anti-VEGF siRNA (bevasiranib) by incorporating supramolecular assemblies of hydrophobically modified polyamidoamine dendrimer in stealth liposomes

Hydroxyl-modified magnetite nanoparticles as novel carrier for delivery of methotrexate

Design, preparation, and in vitro characterization of a trimodally-targeted nanomagnetic onco-theranostic system for cancer diagnosis and therapy

Effects of phosphate supplementation on Pseudomonas aeruginosa invasive behavior in burn wound infections: A simple approach to a big problem

Trachyspermum ammi 10 % topical cream versus placebo on neuropathic pain, a randomized, double-blind, placebo-controlled trial

Cholesterol-conjugated supramolecular assemblies of low generations polyamidoamine dendrimers for enhanced EGFP plasmid DNA transfection

Design and cell cytotoxicity assessment of palmitoylated polyethylene glycol‐grafted chitosan as nanomicelle carrier for paclitaxel

Effects of Quince syrup on clinical symptoms of children with symptomatic gastroesophageal reflux disease: A double-blind randomized controlled clinical trial

Controlled size synthesis and application of nanosphere MCM-41 as potent adsorber of drugs: A novel approach to new antidote agent for intoxication

A Comparison between the Nephrotoxic Profile of Gentamicin and Gentamicin Nanoparticles in Mice

Randomized and double-blinded clinical trial of the safety and calcium kidney stone dissolving efficacy of Lapis judaicus

Hydatid cyst formation in male Balb/c mice following the intraperitoneal injection of live protoscoleces and activated oncospheres: a comparative study

Nanostructure l-asparaginase-fatty acid bioconjugate: Synthesis, preformulation study and biological assessment

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