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TheKlebsiella pneumoniaeplasmid pJHCMW1 harbors a copy of Tn1331,a multiresistance transposon that includes theaac(6′)-Ibgene which encodes a 6′-N-aminoglycoside acetyltransferase. This gene was mutagenized using the mutatorEscherichia coliXL1-Red. Two plasmids with a single nucleotide mutation inaac(6′)-Ibwere selected for further analysis: pDP1 and pDP6. Plasmid pDP1 codes for a mutant enzyme, AAC(6′)-Ib...