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Structural data on the Ca 2+ -ATPase of sarcoplasmic reticulum are integrated with kinetic data on Ca 2+ transport. The emphasis is upon ATPase-ATPase interactions, the requirement for phospholipids, and the mechanism of Ca 2+ translocation. The possible role of cytoplasmic [Ca 2+ ] in the regulation of the synthesis of Ca 2+ -ATPase...
The ATP-dependent Ca 2+ transport in sarcoplasmic reticulum involves transitions between several structural states of the Ca 2+ -ATPase, that occur without major changes in the secondary structure. The rates of these transitions are modulated by the lipid environment and by interactions between ATPase molecules. Although the Ca 2+ -ATPase restricts the rotational...
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