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Therapeutic vaccination is a novel treatment approach for chronic hepatitis B, but only had limited success so far. We hypothesized that optimized vaccination schemes have increased immunogenicity, and aimed at increasing therapeutic hepatitis B vaccine efficacy.Modified Vaccinia virus Ankara (MVA) expressing hepatitis B virus (HBV) antigens was used to boost protein-prime vaccinations in wildtype...
Several correlates of HIV control have been described; however their predictive values remain unclear, since most studies have been performed in cross-sectional settings.We evaluated the cause and consequence relationship between quality of HIV-specific T-cell response and viral load dynamic in a temporal perspective.HIV-1-specific T-cell responses were monitored over 7 years in a patient that following...
Here we report a novel strategy for the induction of CD8 + T cell adaptive immune response against viral and tumor antigens. This approach relies on high levels of incorporation in HIV-1 VLPs of a mutant of HIV-1 Nef (Nef mut ) which can act as anchoring element for foreign proteins. By in vitro assay, we found that VLP-associated Nef mut is efficiently cross-presented by antigen...
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