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The goal of this study was to assess the prognostic significance of midwall and infarct patterns of late gadolinium enhancement (LGE) in aortic stenosis.Myocardial fibrosis occurs in aortic stenosis as part of the hypertrophic response. It can be detected by LGE, which is associated with an adverse prognosis in a range of other cardiac conditions.Between January 2003 and October 2008, consecutive...
We hypothesized that improved survival of internal mammary artery (IMA) conduits compared to saphenous vein grafts (SVG) may be due to preserved endothelial nitric oxide (NO) activity in arterial grafts. For this purpose, we studied endothelium-dependent and -independent dilator and constrictor functions in IMA (N = 6), SVG (N = 25), and native atherosclerotic vessels (NAV) (N = 30) in 30 patients...
Because of increasing evidence that human cytomegalovirus (CMV) pre-disposes to atherosclerosis, we determined whether different immune responses to CMV occur in immunocompetent individuals and, if so, whether the specific type of immune response correlates with coronary artery disease (CAD). 166 patients (pts) (64% men, 36% women, mean age 57) being evaluated for CAD were studied. Blood samples...
Although dobutamine (D) is routinely used as a surrogate for exercise, there is often discordance between exercise and D stress tests, especially in pts with mild coronary artery disease (CAD). While physical exercise causes myocardial ischemia by a combination of increase in demand and epicardial coronary (EC) constriction, it is not known whether constriction plays a role in D-induced ischemia...
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