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Google Trends (GT) offers a historical database of global internet searches with the potential to complement conventional records of environmental hazards, especially in regions where formal hydrometeorological data are scarce. We evaluate the extent to which GT can discern heavy rainfall and floods in Kenya and Uganda during the period 2014 to 2018. We triangulate counts of flood searches from GT...
Adenomatous polyposis coli (APC) mutations cause Wnt pathway activation in human cancers. Current models for APC action emphasize its role in promoting β-catenin degradation downstream of Wnt receptors. Unexpectedly, we find that blocking Wnt receptor activity in APC-deficient cells inhibits Wnt signaling independently of Wnt ligand. We also show that inducible loss of APC is rapidly followed by Wnt...
Lung adenocarcinoma (AdC) and lung squamous cell carcinoma (SCC) are the most common non‐small cell lung cancer (NSCLC) subtypes, however, most genetic mouse models of lung cancer produce predominantly, if not exclusively, AdC. Whether this is secondary to targeting mutations to the distal airway cells or to the use of activating Kras mutations that drive AdC formation is unknown. We previously showed...
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